K. Nario et al., THE EFFECT OF ADENOSINE ON COCHLEAR POTENTIALS IN THE GUINEA-PIG, European archives of oto-rhino-laryngology, 251(7), 1994, pp. 428-433
The effect of adenosine on cochlear potentials was examined in the gui
nea pig. Perilymphatic perfusion with 10(-4) M adenosine produced a si
gnificant decrease in the amplitudes of cochlear microphonics, negativ
e summating potential (-SP) and compound action potential (CAP) and si
gnificant prolongation of N1 latency with no change in the endocochlea
r potential. The decreases in the amplitudes of -SP and CAP caused by
adenosine were dose-dependent. Perilymphatic perfusion with an inactiv
e analogue, 8-bromoadenosine, produced no changes in the cochlear pote
ntials. The A1-receptor agonist, 2-chloroadenosine, produced a similar
change in cochlear potentials to adenosine, while no changes were pro
duced by the A2-receptor agonist ,5'-(N-ethylcarboxamido)-adenosine. T
hese results suggest that adenosine may have a medulatory function thr
ough an A1 receptor in the cochlea.