A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-LIKE FC RECEPTOR CLONED FROM HUMAN PLACENTA - POSSIBLE ROLE IN TRANSFER OF IMMUNOGLOBULIN-G FROMMOTHER TO FETUS

Citation
Cm. Story et al., A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-LIKE FC RECEPTOR CLONED FROM HUMAN PLACENTA - POSSIBLE ROLE IN TRANSFER OF IMMUNOGLOBULIN-G FROMMOTHER TO FETUS, The Journal of experimental medicine, 180(6), 1994, pp. 2377-2381
Citations number
30
Categorie Soggetti
Immunology,"Medicine, Research & Experimental
ISSN journal
00221007
Volume
180
Issue
6
Year of publication
1994
Pages
2377 - 2381
Database
ISI
SICI code
0022-1007(1994)180:6<2377:AMHCCI>2.0.ZU;2-T
Abstract
The acquisition of maternal antibodies is critical for immunologic def ense of the newborn. In humans, maternal IgG is actively transported a cross the placenta. The receptor responsible for this transport has no t been identified definitively. We report the isolation from a placent al cDNA library of clones encoding the or-chain of an immunoglobulin G (IgG)-Fc receptor (hTcRn) that resembles a class I major histocompati bility complex antigen. The DNA and predicted amino resembles a class I histocompatibility complex antigen. The DNA and predicted amino acid sequences are very similar to those of the neonatal rat and mouse int estinal Fc receptors, rFcRn and mFcRn. These receptors mediate transpo rt of maternal IgG from milk to the bloodstream of the suckling rat or mouse. Like rat and mouse FcRn, hFcRn binds IgG preferentially at low PH, which may imply that IgG binds hFcRn in an acidic intracellular c mpartment during transport across the placenta.