FIXED DRUG ERUPTION OF THE PENIS DUE TO HYDROXYZINE HYDROCHLORIDE

OBJECTIVE: TO report four cases of fixed drug eruption induced by hydr oxyzine hydrochloride (Otarex, Teva, Israel), CASE SUMMARY: Four child ren with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was f ollowed by complete resolution of the skin eruption, Rechallenge resul ted in the same drug rash, Macrophage migration inhibiting factor (MIE ) assay with hydroxyzine hydrochloride was positive, DISCUSSION: The p athogenesis of fixed drug eruption and the role of macrophage MIF assa y in diagnosis is discussed, CONCLUSIONS: A fixed drug eruption induce d by hydroxyzine hydrochloride is possible, but is a rare phenomenon.