INTERACTION BETWEEN BARICITY (GLUCOSE-CONCENTRATION) AND OTHER FACTORS INFLUENCING INTRATHECAL DRUG SPREAD

Citation
P. Sanderson et al., INTERACTION BETWEEN BARICITY (GLUCOSE-CONCENTRATION) AND OTHER FACTORS INFLUENCING INTRATHECAL DRUG SPREAD, British Journal of Anaesthesia, 73(6), 1994, pp. 744-746
Citations number
5
Categorie Soggetti
Anesthesiology
ISSN journal
00070912
Volume
73
Issue
6
Year of publication
1994
Pages
744 - 746
Database
ISI
SICI code
0007-0912(1994)73:6<744:IBB(AO>2.0.ZU;2-9
Abstract
The effects of intrathecal injection of 0.5% bupivacaine in solutions containing various concentrations of glucose have been studied in four groups of 20 patients. When solutions containing 0.8% glucose were in jected at the L3-4 interspace the median maximum extent of block was h igher, and the range of blocks wider, with the 8% solution. All patien ts receiving 0.8% glucose had blocks between the T5 and T10 dermatomes , confirming previous work on the benefits of this concentration of gl ucose. In the two other groups 0.5% bupivacaine containing 0 or 0.8% g lucose was injected at the L2-3 interspace. In both groups of patients a wider range of blocks, with a median maximum extent that was higher , was produced. These results demonstrate how glucose concentration ma y be used to influence the spread of intrathecal solutions and how oth er factors can obscure the effect of glucose concentration.