DETERMINATION OF OXYBUTYNINE HYDROCHLORID E BY DIFFERENTIAL-PULSE POLAROGRAPHY

A differential pulse polarographic (DPP) method was developed for the determination of oxybutynine hydrochloride in Ditropan (R) tablets wit hout interference from excipients. Oxybutynine reacts at the dropping mercury electrode resulting in two irreversible peaks. Linearity betwe en the oxybutynine concentration and the peak height was observed in t he 2 x 10(-4)-2.5 x 10(-6) M concentration range. The detection limit is 0.6 mu g/ml. The analysis of a series of 10 Ditropan (R) 5 mg table ts showed a standard deviation of +/- 0.076 mg and a S-rel of +/- 1.53 %, respectively.