PREPARATION OF 6,14-ETHENOMORPHINAN DERIV ATIVES

Authors
MARTON J HOSZTAFI S BERENYI S SIMON C MAKLEIT S
Citation
J. Marton et al., PREPARATION OF 6,14-ETHENOMORPHINAN DERIV ATIVES, Monatshefte fuer Chemie, 125(11), 1994, pp. 1229-1239
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Monatshefte fuer Chemie → ACNP
ISSN journal
00269247
Volume
125
Issue
11
Year of publication
1994
Pages
1229 - 1239
Database
ISI
SICI code
0026-9247(1994)125:11<1229:PO6DA>2.0.ZU;2-K
Abstract
Dihydronorthevinone (2b) was prepared from dihydrothevinone (2a) with diethyl azodicarboxylate (DEAD) and transformed into a number of new N -substituted dihydronorthevinone derivatives (2c-2g). Grignard reactio ns of the new compounds with methylmagnesium iodide and tert-butyl-mag nesium chloride were studied. O-Demethylation of 3a-3j resulted in the corresponding N-substituted buprenorphine and diprenorphine analogs 4 a-4j.