REACTION OF SCHIFF-BASES OF 1-TETRALONE WITH ACID-CHLORIDES - STEREOSELECTIVE SYNTHESIS OF BETA-LACTAMS SPIROANNULATED WITH THE TETRAHYDRONAPHTHALENE RING-SYSTEM

Authors
BOGDANOWICZSZWED K KRASODOMSKA M
Citation
K. Bogdanowiczszwed et M. Krasodomska, REACTION OF SCHIFF-BASES OF 1-TETRALONE WITH ACID-CHLORIDES - STEREOSELECTIVE SYNTHESIS OF BETA-LACTAMS SPIROANNULATED WITH THE TETRAHYDRONAPHTHALENE RING-SYSTEM, Monatshefte fuer Chemie, 125(11), 1994, pp. 1247-1258
Citations number
21
Categorie Soggetti
Chemistry
Journal title
Monatshefte fuer Chemie → ACNP
ISSN journal
00269247
Volume
125
Issue
11
Year of publication
1994
Pages
1247 - 1258
Database
ISI
SICI code
0026-9247(1994)125:11<1247:ROSO1W>2.0.ZU;2-4
Abstract
Arylimines of 1-tetralone (1) react with various substituted acetyl ch lorides (2) in the presence of triethylamine yielding p-lactams spiroa nnulated with tetrahydronaphthalene (3). The stereochemistry of the pr oducts has been determined by NMR methods. Reactions of imines 1 with acid chlorides 2 were proved to be highly stereoselective.