SARCOMAS OF NASAL CAVITY AND PARANASAL SINUSES - CHONDROSARCOMA, OSTEOSARCOMA AND FIBROSARCOMA

Forty-two patients were treated for sarcoma of the nasal cavity and pa ranasal sinuses at the Institut Gustave Roussy, Paris, between 1960 an d 1993. Twelve patients had chondrosarcoma (CS), 14 had osteosarcoma ( OS) and 16 had fibrosarcoma (FS). Ten patients had grade I, six grade II and 26 grade III tumours. All but 10 patients had surgery for the p rimary tumour. A significantly increased risk of local failure was ass ociated with the male sex (p <0.01), grade III tumours (p <0.02) and p atients excluded from surgery (p <0.04). The overall incidence of loca l and distant failure was 76 and 12 per cent respectively. Overall sur vival was 28 per cent at three years and 23 per cent at five years. Ei ght patients (20 per cent) were alive more than 10 years later. The fa ctors significantly influencing survival were sex (p <0.01), grade (p <0.05) and local failure (p < 0.01).