IODIXANOL IN CARDIOANGIOGRAPHY - A DOUBLE-BLIND PARALLEL COMPARISON BETWEEN IODIXANOL 320-MG I ML AND IOXAGLATE 320-MG I/ML/

Iodixanol (Visipaque) 320 mg I/ml, a non-ionic, dimeric, isotonic cont rast medium, was compared to ioxaglate (Hexabrix) 320 mg I/ml in cardi oangiography. One hundred and two patients with normal renal function were included in the study. The objectives were to evaluate safety, to lerability, radiographic efficacy and effects on renal function. Adver se events, discomfort, vital signs, clinical chemistry parameters, dia gnostic information and radiographic density were recorded. Both contr ast media had minor effects on the renal function parameters monitored . The patients who received iodixanol experienced fewer adverse events , significantly less discomfort and had a lower increase in heart rate than did the patients in the ioxaglate group. The radiographic effica cy was good in both groups. Iodixanol 320 mg I/ml is safe and effectiv e for use in cardioangiography.