IODIXANOL IN FEMORAL ARTERIOGRAPHY - A RANDOMIZED, DOUBLE-BLIND, PHASE-III, PARALLEL STUDY WITH IODIXANOL 270-MG I ML AND IOHEXOL 300-MG I/ML/

Two contrast media, iodixanol (Visipaque, Nycomed) 270 mg I/ml and ioh exol (Omnipaque, Nycomed) 300 mg I/ml, were compared in femoral arteri ography, in 147 patients. Both contrast media were diagnostically effe ctive for use in femoral arteriography, without any significant differ ence. Pain was reported in connection with injection of iohexol by 36% of the patients, after injection of iodixanol none reported pain. Sev enty-two percent of the patients in the iodixanol group reported a sen sation of warmth in connection with contrast injection versus 90% in t he iohexol group. The average intensity of the warmth was greater with iohexol than with iodixanol. Fourteen percent of patients in the iodi xanol group and 1% in the iohexol group reported one or more subjectiv e adverse events.