At present, alcohol is recognized as the leading teratogenic agent in
long-lasting CNS dysfunction. Little is known about the long-term deve
lopment and outcome of children with fetal alcohol syndrome (FAS). For
ty-four FAS patients who were diagnosed in early childhood were follow
ed up for 10-14 years. This study documents the developmental changes
of the manifestations of FAS from childhood to adolescence and describ
es a characteristic ''juvenile'' pattern of FAS, which may help to ide
ntify this syndrome even in adolescence. This is especially relevant f
or patients who were not diagnosed earlier.