VASOPRESSIN INHIBITS FOOD-INTAKE IN PYGMY GOATS BY ACTIVATION OF ALPHA(1)-ADRENERGIC RECEPTORS

Vasopressin (VP) is known to reduce food intake in pygmy goats. The hy pophagic effect of intraperitoneally injected VP (1.5 pg/kg) was block ed by concomitant injection of the alpha(1)-adrenergic antagonist praz osin (27 and 40 mu g/kg). Both the alpha(2)-adrenergic antagonists ida zoxan (300 mu g/kg) and yohimbine (500 pg/kg) and the beta-adrenergic antagonist propranolol (500 pg/kg) failed to block the hypophagia indu ced by VP (1.5 mu g/ kg). The results suggest that the hypophagic effe ct of VP is mediated by alpha(1)-adrenergic receptors.