TECHNICAL REPORT - THE SUBCUTANEOUS ADMINISTRATION OF COCAINE IN THE RAT

Authors
DURAZZO TC GAUVIN DV GOULDEN KL BRISCOE RJ HOLLOWAY FA
Citation
Tc. Durazzo et al., TECHNICAL REPORT - THE SUBCUTANEOUS ADMINISTRATION OF COCAINE IN THE RAT, Pharmacology, biochemistry and behavior, 49(4), 1994, pp. 1007-1010
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
49
Issue
4
Year of publication
1994
Pages
1007 - 1010
Database
ISI
SICI code
0091-3057(1994)49:4<1007:TR-TSA>2.0.ZU;2-Q
Abstract
Eight male Sprague-Dawley rats were treated with 32 mg/kg cocaine, twi ce daily, for 2 weeks using a SC route of administration. Using a coca ine stock solution of 1.2-1.6 mg of cocaine hydrochloride per mi of st erile saline, we demonstrate, for the first time, the relative safety of subcutaneously administered cocaine in the rat. There was absolutel y no evidence for focal dermal necrosis, in any rat, after the 2-week chronic period.