EFFECTS OF BRAIN-TISSUE HYDROLYSATE ON SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS

Authors
BASKYS A WOJTOWICZ JM
Citation
A. Baskys et Jm. Wojtowicz, EFFECTS OF BRAIN-TISSUE HYDROLYSATE ON SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS, Pharmacology, biochemistry and behavior, 49(4), 1994, pp. 1105-1107
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
49
Issue
4
Year of publication
1994
Pages
1105 - 1107
Database
ISI
SICI code
0091-3057(1994)49:4<1105:EOBHOS>2.0.ZU;2-P
Abstract
A mix of peptides and amino acids obtained from porcine brain tissue ( Cerebrolysin) has been shown to affect passive avoidance behavior in n eonatal rats. To identify the active components and mechanisms of acti on, Cerebrolysin effects were studied in in vitro hippocampal slices. Cerebrolysin induced dose-dependent suppression followed by a small re bound increase of synaptic responses in the CA1 but not dentate gyrus neurons. These actions may be due to peptides present in Cerebrolysin and may contribute to its reported behavioural effects.