SYNTHESIS OF SULFONATED HYALURONAN DERIVATIVES CONTAINING NUCLEIC-ACID BASES

Authors
WADA T CHIRACHANCHAI S IZAWA N INAKI Y TAKEMOTO K
Citation
T. Wada et al., SYNTHESIS OF SULFONATED HYALURONAN DERIVATIVES CONTAINING NUCLEIC-ACID BASES, Chemistry Letters, (11), 1994, pp. 2027-2030
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
11
Year of publication
1994
Pages
2027 - 2030
Database
ISI
SICI code
0366-7022(1994):11<2027:SOSHDC>2.0.ZU;2-Y
Abstract
The conjugation of nucleic acid base with sulfonated hyaluronan was ac hieved by the ring opening reaction of 1,2-O-ethano derivatives of nuc leic acid bases, The conditions of sulfonation of sodium hyaluronate w ere studied. Thymine and 5-bromouracil base were quantitatively conjug ated to sulfonated hyaluronan in 15% and 24%, respectively.