SPECIFIC INCLUSION OF WATER BY N-METHYLDEOXYCHOLANAMIDE REVEALED BY THE CRYSTAL-STRUCTURE OF THE HEMIHYDRATE

Authors
SADA K HISHIKAWA Y KONDO T MIYATA M
Citation
K. Sada et al., SPECIFIC INCLUSION OF WATER BY N-METHYLDEOXYCHOLANAMIDE REVEALED BY THE CRYSTAL-STRUCTURE OF THE HEMIHYDRATE, Chemistry Letters, (11), 1994, pp. 2113-2116
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
11
Year of publication
1994
Pages
2113 - 2116
Database
ISI
SICI code
0366-7022(1994):11<2113:SIOWBN>2.0.ZU;2-N
Abstract
N-Methyldeoxycholanamide specifically includes water instead of organi c substances, which is in contrast to deoxycholic acid and deoxycholan amide. Such a specific inclusion behaviour is reasonably explained by the crystal structure of the hemihydrate. The N-methyl group induces a ladder-like hydrogen bonding scheme involving water. The resulting mo lecular arrangement inhibits an inclusion of organic guests.