SYNTHESIS OF THE TETRAHYDROFURAN RING PART OF A MARINE TOXIN POLYCAVERNOSIDE-A

Authors
HAYASHI N MINE T FUJIWARA K MURAI A
Citation
N. Hayashi et al., SYNTHESIS OF THE TETRAHYDROFURAN RING PART OF A MARINE TOXIN POLYCAVERNOSIDE-A, Chemistry Letters, (11), 1994, pp. 2143-2146
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
11
Year of publication
1994
Pages
2143 - 2146
Database
ISI
SICI code
0366-7022(1994):11<2143:SOTTRP>2.0.ZU;2-F
Abstract
Construction of the tetrahydrofuran ring part of polycavernoside A, wh ich has been isolated as one of toxic principles from the red alga Pol ycavernosa tsudai, is described starting from 2,2-dimethylpropane-1,3- diol. The synthesis involves the Sharpless epoxidation and the Evans p rocedure for introduction of three chiral centers.