2,4,4-TRIMETHYL-2H-1,2-BENZOSELENAZIN-3(4H)-ONE

Authors
DUPONT L JACQUEMIN P
Citation
L. Dupont et P. Jacquemin, 2,4,4-TRIMETHYL-2H-1,2-BENZOSELENAZIN-3(4H)-ONE, Acta crystallographica. Section C, Crystal structure communications, 50, 1994, pp. 1801-1802
Citations number
9
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
50
Year of publication
1994
Part
11
Pages
1801 - 1802
Database
ISI
SICI code
0108-2701(1994)50:<1801:2>2.0.ZU;2-K
Abstract
The title compound, C11H13NOSe, is a derivative of ebselen, an organos elenium compound which exhibits anti-inflammatory activity. The aim of the modification of the ebselen molecular structure is to increase th e solubility of the compound without modifying the pharmacological pro perties. The Se-N bond [1.859(5)Angstrom] is included in a six-membere d ring, which has a boat conformation. The value of the C-Se-N angle i s 95.2(2)degrees. The cohesion of the crystal is the result of van der Waals interactions.