HISTOPATHOLOGIC INVESTIGATIONS OF ACUTE AND SUBCHRONIC TOXICITIES OF SOME ORGANOTIN COMPOUNDS IN CHICKENS

Authors
SOCACIU C BABA AI ROTARU O
Citation
C. Socaciu et al., HISTOPATHOLOGIC INVESTIGATIONS OF ACUTE AND SUBCHRONIC TOXICITIES OF SOME ORGANOTIN COMPOUNDS IN CHICKENS, Veterinary and human toxicology, 36(6), 1994, pp. 535-539
Citations number
32
Categorie Soggetti
Toxicology,"Veterinary Sciences
Journal title
Veterinary and human toxicology → ACNP
ISSN journal
01456296
Volume
36
Issue
6
Year of publication
1994
Pages
535 - 539
Database
ISI
SICI code
0145-6296(1994)36:6<535:HIOAAS>2.0.ZU;2-F
Abstract
The acute and subchronic oral toxicities of 4 organotin derivatives we re investigated in chickens. The LD(50) values oscillated between 200 and 400 mg/kg bw and revealed a moderate or weak toxicity. Subchronic dosing with 2 doses from each compound at 2 and 10 mg/kg bw induced do se-dependent lesions seen at necropsy and histologic examinations. Inv olution of the thymus and bursa Fabricius fatty degeneration of the li ver, and nephrotic syndromes were the most evident effects. The butylt in derivatives induced more drastic lesions than did the phenyltins.