Background. - Hyperglycemia as the first manifestation of neonatal sep
sis is rare. Case report. - A breast-fed neonate was admitted at the a
ge of 6 days because of vomiting. Group B streptococci had been isolat
ed in secretions of the ear at birth but the neonate had not been trea
ted. At admission, physical examination was normal but glucosuria, wit
hout ketonuria, and hyperglycemia (9.7 mmol/l) were noted. Because hyp
erglycemia was not explained by usual causes, the baby was systematica
lly given antibiotics. The next day, blood, spinal fluid and urine cul
tures taken on admission were positive for group B streptococci while
blood fibrinogen and C-reactive protein were increased. Hyperglycemia
and glycosuria were normal after 24 hours of antibiotic therapy and fo
llow-up was uneventful. Subsequently, the same bacteria was isolated f
rom the mother's milk. Conclusion. - Isolated hyperglycemia may reveal
an infection; therefore its discovery might contribute to early diagn
osis and treatment.