LONG-TERM SYNAPSE LESS INDUCED BY FOCAL BLOCKADE OF POSTSYNAPTIC RECEPTORS

Authors
BALICEGORDON RJ LICHTMAN JW
Citation
Rj. Balicegordon et Jw. Lichtman, LONG-TERM SYNAPSE LESS INDUCED BY FOCAL BLOCKADE OF POSTSYNAPTIC RECEPTORS, Nature, 372(6506), 1994, pp. 519-524
Citations number
49
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
372
Issue
6506
Year of publication
1994
Pages
519 - 524
Database
ISI
SICI code
0028-0836(1994)372:6506<519:LSLIBF>2.0.ZU;2-V
Abstract
Focal application in vivo of alpha-bungarotoxin to block neurotransmis sion in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotrans mission throughout a junction does not cause synapse elimination. Thes e and related experiments indicate that active synaptic sites can dest abilize inactive synapses in their vicinity.