Food-borne illness is a vast and costly worldwide problem. Although co
mplex, it may be divided into two major types of animal and human dise
ase: intoxication caused by toxic substances in food and secondly, inf
ection, caused by microorganisms. Toxic substances may be already pres
ent in foods, or they may be produced by microorganisms through contam
ination and proliferation in food. Prevention of the invasion of foods
by microorganisms may be achieved by effective use of intrinsic facto
rs found in plants and animals. These factors include pH, moisture con
tent, oxidation-reduction potential, nutrient content, biological stru
ctures, and antimicrobial constituents. A second type of natural prote
ction is that of microbial antagonism. Research work discussed include
s that done in the author's laboratories involving tannic acid and mic
robial antagonism against Listeria monocytogenes in milk. The safety o
f all natural mechanisms of defense is important economically and in p
ublic health. We predict that the use of antimicrobials occurring natu
rally in foods and safe microbial antagonism will receive more attenti
on in future food safety research.