FURTHER EVIDENCE THAT ARTHROGRYPOSIS MULTIPLEX CONGENITA IN THE HUMANSOMETIMES IS CAUSED BY AN INTRAUTERINE VASCULAR ACCIDENT

A 7-1/2-year-old girl with arthrogryposis multiplex congenita of the a myoplasia type in association with intestinal atresias, gastroschisis, Mobius anomaly, and hypoplasia of the pectoral, biceps, and deltoid m uscles is described. Several combinations of these birth defects have been previously described. There is considerable evidence that gastros chisis, intestinal atresia, Poland sequence, and Mobius anomaly each h as a vascular pathogenesis. Based on the associations seen in this chi ld and past reports of more limited, similar cooccurrences, we suggest that arthrogryposis multiplex congenita may sometimes be caused by an intrauterine vascular catastrophe.