CONTROLLED CISPLATIN DELIVERY SYSTEM USING POLY(D,L-LACTIC ACID)

Cisplatin (CDDP)-containing poly(D,L-lactic acid) microspheres (CDDP-M S) and beads (CDDP-B) with an average molecular weight of the oligomer of 1.2 x 10(4) and 4% CDDP loading were prepared. in Tris buffer, 95% of CDDP disappeared from CDDP-MS within 3 d. In vitro and in vivo, CD DP-B released CDDP for 30-57 d, and for 21-42 d, respectively. The oth er CDDP-B with an average oligomer molecular weight of 9.6 x 10(3) wit h 5% lactic acid monomers, that contained 4% CDDP, showed a two-phase CDDP release pattern and CDDP disappeared within 41 d in vitro, and wi thin 21 d in vivo. Histologically, tissue necrosis surrounding the CDD P-B was not severe.