EFFECT OF TROSPIUM CHLORIDE ON DUODENAL MOTILITY DURING UPPER GASTROINTESTINAL ENDOSCOPY - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

In a placebo-controlled, double-blind study the effects of depressing duodenal motility by administration of intravenous trospium chloride d uring gastroduodenoscopy were studied in 72 patients randomised to rec eive trospium chloride or saline (controls). Intravenous trospium chlo ride 1.2mg stopped the visible contractile activity of the duodenum as assessed by 3 independent observers during videoendoscopy within 76 s econds (median). During a 4-minute observation period of duodenal peri stalsis, duodenal motor activity was found to stop in 18 of 36 patient s after trospium chloride but in only 5 of 36 patients in the placebo group (p = 0.002). Adverse effects were dry mouth, micturition difficu lties, sweat retention, accommodation disturbance and tachycardia. Tro spium chloride was effective in reducing contractile activity in the d uodenum. Its potent action and minor adverse effect profile appear to be promising for gastroduodenoscopy and especially for sphincter of Od di motility in patients during routine endoscopic retrograde cholangio pancreatography.