G. Andronico et al., INSULIN RESISTANCE AND ENDOGENOUS DIGOXIN-LIKE FACTOR IN OBESE HYPERTENSIVE PATIENTS WITH GLUCOSE-INTOLERANCE, Acta diabetologica, 28(3-4), 1992, pp. 203-205
Hypertensive obese subjects with glucose intolerance have hyperinsulin
aemia, insulin resistance and intracellular cation imbalance resulting
in increased sodium content. The aim of our study was to assess in th
ese patients plasma levels of endogenous digoxin-like factor (EDLF), a
n inhibitor of the sodium-pump mechanism. We studied 14 hypertensive a
nd 12 normotensive subjects with obesity and glucose intolerance for f
asting blood glucose, and plasma insulin, C-peptide and EDLF levels: t
he two groups were matched for age and BMI and were studied after a 2-
week wash-out period from hypotensive drugs. Compared with normotensiv
es, hypertensive subjects had higher plasma insulin levels, a greater
immunoreactive insulin/C-peptide ratio, a lower glucose/insulin ratio
and higher plasma EDLF levels. Our results confirm that among obese pe
ople with glucose intolerance, hypertensives are more hyperinsulinaemi
c and insulin-resistant than normotensives and indicate that the intra
cellular cation imbalance in these patients may be attributable, at le
ast in part, to EDLF.