SCLEROMYXEDEMA - CASE-REPORT AND REVIEW OF THE TREATMENT OPTIONS

We report on a 54-year-old patient with an 11-year history of Arndt-Go ttron scleromyxoedema. We found typical lichenoid papules, diffuse ski n thickening and skin hardening. Clinical and laboratory investigation s revealed a monoclonal gammopathy of the IgG1 type, normal histology of the bone marrow and normal urine. Therefore, a diagnosis of monoclo nal gammopathy of undetermined significance was recorded. Phimosis and stenosis of the urethra were the only other pathologic findings. Syst emic treatment with chlorambucil and PUVA had little beneficial effect on the skin thickening after 9 months.