SURVIVAL OF HEMOPHILIC MALES WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME WITH AND WITHOUT RISK-FACTORS FOR AIDS OTHER THAN HEMOPHILIA

Between January 1, 1981, and June 30, 1990, 1,514 hemophilia-associate d acquired immunodeficiency syndrome (AIDS) cases in males were diagno sed in the United States. In 1,394, hemophilia was reported as the sol e risk factor. For an additional 120, other risk factors were reported : of 101 ot these, 40 had homosexual/bisexual activity, 53 had a histo ry of intravenous drug use, and 8 had both of these risk factors. We e xamined the demographic data and the survival data of two principal gr oups: males for whom hemophilia was the sole reported risk factor for human immunodeficiency virus (HIV) exposure. and hemophilic males for whom homosexual/bisexual activity, intravenous drug use, or both of th ese additional risk factors were reported. The survival curves showed marginal differences between the hemophilia-only and the multiple risk groups; the median survival times were 13.1 and 14.6 months, with the cumulative probability of survival at 1 year as 52.7% and 54.0%, resp ectively. Kaposi's sarcoma was among AIDS indicator diseases more comm only found in the multiple risk factor group. Pneumocystis carinii pne umonia was the sole reported diagnosis indicative of AIDS for 34.4% of those in the hemophilia-only group, compared with 20.8% of those with multiple risk factors. The principal demographic difference between t he two groups was the age distribution; those in the multiple risk fac tor group were primarily between 20 and 44 years of age. Restricting t he analysis to those between 20 and 44 years resulted in a slightly lo nger survival time in the hemophilia-only group and no appreciable dif ference between the disease distributions and survival curves of the t wo groups.