A FACTORIAL STUDY OF SALT RESTRICTION AND A LOW-FAT HIGH-FIBER DIET IN HYPERTENSIVE SUBJECTS

Objective: To compare the independent and additive effects of sodium r estriction and a low-fat, high polyunsaturated: saturated fatty acids (P:S) ratio, high-fibre diet upon blood pressure. Design: A randomized , parallel, double-blind, placebo-controlled (for sodium) 2x2 factoria l trial. Setting: Clinical. Participants: Ninety-five hypertensive sub jects (mean blood pressure, 137/83 mmHg), mean age 53.5 years, consumi ng < 30 ml ethanol/day were selected from community volunteers. Sevent y-nine treated and twelve untreated hypertensives completed the trial. Intervention: Subjects followed either a low-sodium, low-fat/high-fib re diet (< 60 mmol sodium/day; 30% fat energy; P:S ratio = 1; 30-50 g fibre/day) or a low-sodium, normal-fat/normal-fibre diet ( < 60 mmol s odium/day; 40% fat energy; P:S ratio = 0.3; 15 g fibre/day) for 8 week s. Half of each group received 100 mmol/day NaCl and the remainder rec eived placebo. Main outcome measures: Blood pressure and blood lipids. Results: Sodium restriction significantly reduced standing and supine systolic blood pressure, with no effect upon diastolic blood pressure . The low-fat/high-fibre diet had no effect upon blood pressure, but s ignificantly reduced total cholesterol, low-density lipoprotein choles terol and high-density lipoprotein cholesterol. Conclusions: Sodium re striction reduced blood pressure and did not raise low-density lipopro tein cholesterol. A low-fat/high-fibre diet did not reduce blood press ure but lowered cholesterol levels. A combination of the two regimes h as the greater potential for reducing cardiovascular risk in hypertens ives.