Under the Wireless Technology Research, L.L.C. (WTR) program, epidemio
logy studies are considered in the context of both postmarketing surve
illance and as tools to test specific cause-effect hypotheses to suppl
ement experimental studies. Neither experimental studies nor epidemiol
ogical studies alone can provide a solid basis for assessing the poten
tial public health impact of wireless communication technology. Theref
ore, results of studies from each of these distinct disciplines must b
e considered and interpreted in the context of the other, and answers
regarding public health risk must follow from a weight-of-evidence eva
luation. No previous epidemiology studies have been conducted on cellu
lar telephone users. Therefore, a series of epidemiology studies of ap
propriate designs (e.g., cohort, case-control) can assess the potentia
l health risks derived from exposures to radiofrequency radiation from
cellular telephone usage. Different study designs are necessary to fu
lly evaluate possible causal associations, with cohort studies allowin
g for evaluation of a wide range of health outcomes, and case-control
studies providing results concerning disease-specific hypotheses.