A case of acute hepatitis induced by zidovudine in a 38-year-old patie
nt with AIDS is, presented. The mechanism whereby the hepatitis was in
duced is not known. However, the patient tolerated well an alternative
reverse transcriptase inhibitor, 2' 3' dideoxyinosine. Physicians car
ing for patients with AIDS should be aware of this hitherto rarely rep
orted complication.