COMPARATIVE ABSORPTION OF ATROPINE FROM A METERED-DOSE INHALER AND ANINTRAMUSCULAR INJECTION

The inhalation of atropine sulfate from a pressurized metered-dose inh aler was investigated in a nonrandomized four-period rising-dose study . Eight healthy, nonsmoking subjects received 1.7, 3.4, and 5.2 mg of atropine sulfate by inhalation and 1.67 mg of atropine free base (equi valent to 2 mg of atropine sulfate) by intramuscular (i.m.) injection. Serum atropine sulfate concentrations were measured over a 24-h perio d by gas chromatography/mass spectrometry. Mean serum concentrations i ncreased nonproportionally as the inhaled dose increased. Mean peak co ncentrations were 4.9, 6.1, and 7.9 ng/ml for the inhaled doses and 8. 4 ng/ml for the i.m. dose. Typical anticholinergic effects were seen a fter all doses.