THE EFFECT OF N-DEACETYLCOLCHICEINE ON SERUM-LIPOPROTEINS IN RATS

N-Deacetylcolchicine (DAC) administered i.p. to rats decreased the lev el of serum cholesterol and apoB. It was accompanied by the fall of HD L-C due to the decrease of both HDL subfractions HDL(a) and HDL(b), an d by a rather weaker decrease of LDL-C. The levels of serum and lipopr otein triacylglycerols were not significantly affected. The "clearing reaction" to heparin in DAC rats differed from controls with regard to plasma cholesterol resulting in its accumulation in HDL(a) and LDL si multaneously with an increased activity of post-heparin lipoprotein li pase. These results suggest that the DAC accelerates the lipoprotein c holesterol metabolism.