BENZOPHENANTHRIDINE ALKALOIDS ISOLATED FROM ESCHSCHOLTZIA-CALIFORNICACELL-SUSPENSION CULTURES INTERACT WITH VASOPRESSIN(V1) RECEPTORS

Authors
GRANGER I SERRADEILLEGAL C AUGEREAU JM GLEYE J
Citation
I. Granger et al., BENZOPHENANTHRIDINE ALKALOIDS ISOLATED FROM ESCHSCHOLTZIA-CALIFORNICACELL-SUSPENSION CULTURES INTERACT WITH VASOPRESSIN(V1) RECEPTORS, Planta medica, 58(1), 1992, pp. 35-38
Citations number
17
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
58
Issue
1
Year of publication
1992
Pages
35 - 38
Database
ISI
SICI code
0032-0943(1992)58:1<35:BAIFE>2.0.ZU;2-D
Abstract
Chelerythrine and sanguinarine, two benzophenanthridine alkaloids, hav e been isolated from a crude methanolic extract of Eschscholtzia calif ornica cell suspension cultures by successive fractionations. These tw o molecules exhibited affinity for rat liver vasopressin V1 receptors and are competitive inhibitors of [H-3]-vasopressin binding within the micromolar range (K(i)). Chelerythrine and sanguinarine represent two of the first non-peptidic structures providing original chemical lead s for the design of synthetic vasopressin compounds.