Citation
La. Khawli et Ai. Kassis, META-[I-125]IODOANILINE - A USEFUL REAGENT FOR RADIOLABELING BIOTIN, International journal of radiation applicatons and instrumentation. Part B: Nuclear medicine and biology, 19(3), 1992, pp. 297-301
Citations number
22
Journal title
International journal of radiation applicatons and instrumentation. Part B: Nuclear medicine and biology
ISSN journal
08832897
→ ACNP
Volume
19
Issue
3
Year of publication
1992
Pages
297 - 301
Database
ISI
SICI code
0969-8051(1992)19:3<297:M-AURF>2.0.ZU;2-D
Abstract
Biotinyl-m-[I-125]iodoanilide (BIA) was synthesized by coupling biotin
to m-[I-125]iodoaniline via a mixed anhydride reaction. m-[I-125]Iodo
aniline was produced from the tin precursor, which was prepared using
a palladium catalyzed reaction of hexabutylditin with m-bromoaniline.
The radioiodinated BIA derivative is characterized by a stable amide a
nd/or intact ureido group on the biotin molecule; it may thus be a use
ful carrier for targeting radionuclides to avidin-conjugated antibodie
s previously localized on tumors.