Citation
Smn. Efange et al., RADIOIODINATED XY-3-(4-IODOPHENYL)-1-(4-PHENYLPIPERIDINYL)PROPANE - POTENTIAL RADIOTRACER FOR MAPPING CENTRAL CHOLINERGIC INNERVATION INVIVO, International journal of radiation applicatons and instrumentation. Part B: Nuclear medicine and biology, 19(3), 1992, pp. 337
Citations number
16
Journal title
International journal of radiation applicatons and instrumentation. Part B: Nuclear medicine and biology
ISSN journal
08832897
→ ACNP
Volume
19
Issue
3
Year of publication
1992
Database
ISI
SICI code
0969-8051(1992)19:3<337:RX-P>2.0.ZU;2-L
Abstract
Radioiodinated y-3-(4-iodophenyl)-1-(4-phenylpiperidinyl)propane, 5 (4
-HIPP), was synthesized and evaluated as a simple vesamicol-like radio
tracer for mapping cholinergic pathways in the brain. Both enantiomers
of 5 exhibit significant accumulation (approx. 2% of injected dose) a
nd prolonged retention (t1/2 > 3 h) within the rat brain. The accumula
tion of radioiodinated 5 in the rat brain was reduced by up to 70% in
the presence of vesamicol and its analogs. The levorotary isomer (-)-4
-[I-123)HIPP exhibits significant accumulation in the monkey brain, wi
th a half-life of about 9 h. Radioiodinated 5 may therefore be a usefu
l tool for studying cholinergic pathways in the brain.