STIMULATORY EFFECTS OF ISLET AMYLOID POLYPEPTIDE (AMYLIN) ON EXOCRINEPANCREAS AND GASTRIN-RELEASE IN CONSCIOUS RATS

A rat islet amyloid polypeptide (amylin), 37-residue peptide amide was synthesized by the Fmoc-based solid phase method and the biological a ctivity of synthetic rat amylin on exocrine pancreas was evaluated for the first time in conscious rat. Amylin (1,10 nmol/kg/h) stimulated p ancreatic exocrine secretion and plasma gastrin concentration. CR-1409 , a CCK receptor antagonist, did not change amylin-stimulated pancreat ic secretion. However, omeprazole (proton pump inhibitor) and atropine inhibited amylin-stimulated pancreatic secretion. This study suggests that amylin may play a role in biological action in the exocrine panc reas possibly mediated by gastric acid hypersecretion.