COMPUTER-PATTERN RECOGNITION - SPONTANEOUS MOTOR-ACTIVITY STUDIES OF RATS FOLLOWING ACUTE EXPOSURE TO TRIETHYLTIN

A computer pattern recognition system, RAPID, was used to measure the spontaneous activity of male Sprague-Dawley rats during six observatio nal periods distributed over 11 days after a single oral dose of triet hyltin bromide (TET) at 3 or 5 mg/kg. These observational periods were distributed between those taken under red light conditions during the animals normal dark cycle (Days 2, 7, and 10 after exposure) and thos e taken under white light conditions during the animals normal light c ycle (Days 3, 6, and 11 after exposure). Significant disruption of the normal behavioral patterns were observed on Days 2 and 7 for the 3 mg /kg-exposed group and on Days 2, 3, 6, 7, and 10 for the 5 mg/kg-expos ed group.