Rectal induction of anaesthesia is a useful method but is not widely u
sed in South Africa. We studied the onset of action and side-effects o
f 1% methohexitone administered rectally in a dose of 20 mg/kg to 110
preschool children. Ninety-one per cent were adequately sedated for in
halation induction by mask within 10 minutes, and all by 15 minutes, o
f drug administration. There was no evidence of significant cardiovasc
ular or respiratory depression and only minor complications such as fa
ecal soiling (11,8%) and hiccough (3,6%) were noted. The technique has
been favourably received by parents, surgeons and nursing staff and h
as now become routine practice.