INFLUENCE OF VARIOUS CONDITIONING REGIMENS ON THE OUTCOME OF BONE-MARROW TRANSPLANTATION FOR LEUKEMIA

Authors
DEVERGIE A SOCIE G ESPEROUBOURDEAU H RIBAUD P TRAINEAU R GLUCKMAN E
Citation
A. Devergie et al., INFLUENCE OF VARIOUS CONDITIONING REGIMENS ON THE OUTCOME OF BONE-MARROW TRANSPLANTATION FOR LEUKEMIA, Nouvelle revue francaise d'hematologie, 33(6), 1991, pp. 437-439
Citations number
17
Journal title
Nouvelle revue francaise d'hematologie → ACNP
ISSN journal
00294810
Volume
33
Issue
6
Year of publication
1991
Pages
437 - 439
Database
ISI
SICI code
0029-4810(1991)33:6<437:IOVCRO>2.0.ZU;2-C
Abstract
Allogeneic bone marrow transplantation is widely used for the treatmen t of leukemias. Relapse is one of the main complications. Various type s of conditioning have been used. Most teams use a combination of cycl ophosphamide and different modalities of total body irradiation. In so me regimens, high does alkylating drugs like Busulfan are substituted for radiation. None of these regimens has modified significantly the l ong term disease free survival, indicating the need for prospective ra ndomized trials.