RECENT TREATMENTS OF APLASTIC-ANEMIA

The treatment of severe aplastic anemia has been modified recently by the demonstration that Cyclosporine A is active alone or in combinatio n leading to more than 50 % response rate. Combination or sequential t reatments with ATG seem to be better than such drug separately but thi s must be studied in randomized studies. Long term follow-up is necess ary to assess the rate of malignant transformation. Growth factors hav e been recently introduced. G or GM-CSF seem to be active. IL-3 has no t been proven to be effective in very small non randomized study. Allo geneic bone marrow transplantation is the best treatment with a matche d related donor, progress must be achieved in methods of conditioning and GVH prophylaxis when a matched unrelated donor is used.