AN APPROACH TO CHANNEL TYPE MOLECULAR-STRUCTURES .1. SYNTHESIS OF BOUQUET-SHAPED MOLECULES BASED ON AN [18]-O6 POLYETHER MACROCYCLE

An approach to a transmembrane cation channel is described. It is base d on the grafting of oxygen bearing side-chains on a macrocyclic polye ther unit that constitutes the organizing core. The resulting species has a structure of overall bouquet shape. The synthesis of such a mole cule B(M)0, 14a is described, together with that of its analogue beari ng polymethylene side-chains B(M)C, 14b. The physicochemical propertie s of these molecules indicate that they possess the features expected on the basis of their structure.