SYNTHESIS OF THIAZOLE, BENZOTHIAZOLE, OXADIAZOLE, THIADIAZOLE, TRIAZOLE AND THIAZOLIDINONE INCORPORATED COUMARINS

3-Bromoacetylcoumarin-(2) obtained by bromination of 3-acetylcoumarin (1) was condensed with 2-amino-4-phenylthiazole, 2-aminothiazole, 2-am inobenzothiazole, 2-amino-4-phenyloxadiazole, 2-aminothiadiazole, 3-am inotriazole to form the corresponding heteroaryl aminoacetylcoumarins (3a-f). The reaction of 2 with thiourea furnished 2-amino-4-(coumariny l-3) thiazole (4) which further reacted with phenylisothiocyanate form ing the unsymmetrical thiourea (5). The thiourea on cyclocondensation with chloroacetic acid gave the thiazolidinone (6) which on further re action with different aromatic aldehydes resulted in the formation of the corresponding arylidene compounds (7). The structures of the produ cts were confirmed from their analytical and spectral data.