TRIHETEROCYCLIC SYDNONE DERIVATIVES OF BIOLOGICAL INTEREST .1. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-ARYL-4-[2-(3'-COUMARYLIDENE HYDRAZINO)-4-THIAZOLYL] SYDNONES

Coumarin coupled with the thiazole ring has been introduced on the pos ition-4-of the 3-arylsydnones via 4-bromoacetyl-3-arylsydnones in a si ngle step method to give the title compounds (4a-l). Preliminary antim icrobial screening of all these compounds has shown antifungal activit y for the methyl and halogen substituted derivatives equal to that of the standard drug.