ANTITUMOR-ACTIVITY OF 1,4-BIS (2'-CHLOROETHYL)-1,4-DIAZABICYCLO-[2.2.1] HEPTANE DIMALEATE (DABIS MALEATE) IN M5076 AND ITS SUBLINE RESISTANT TO CYCLOPHOSPHAMIDE M5 CTX/

Authors
TAGLIABUE G FILIPPESCHI S HENDRICKS H DINCALCI M
Citation
G. Tagliabue et al., ANTITUMOR-ACTIVITY OF 1,4-BIS (2'-CHLOROETHYL)-1,4-DIAZABICYCLO-[2.2.1] HEPTANE DIMALEATE (DABIS MALEATE) IN M5076 AND ITS SUBLINE RESISTANT TO CYCLOPHOSPHAMIDE M5 CTX/, Annals of oncology, 3(3), 1992, pp. 233-236
Citations number
10
Journal title
Annals of oncology → ACNP
ISSN journal
09237534
Volume
3
Issue
3
Year of publication
1992
Pages
233 - 236
Database
ISI
SICI code
0923-7534(1992)3:3<233:AO1(>2.0.ZU;2-J
Abstract
We investigated the antitumoral activity of Dabis Maleate given on dif ferent dosage schedules and as continuous infusion in a murine reticul ar cell sarcoma M5076 (M5) and in a subline made resistant to cyclopho sphamide and other nitrogen mustards (M5/CTX). The therapeutic index o f Dabis Maleate was clearly better when the drug was given as a contin uous 72-h infusion. Dabis Maleate appeared non-cross-resistant to cycl ophosphamide and this property renders it interesting for further clin ical development.