There is considerable interest in imaging of molecular species with th
e STM, due to the potentially very high resolution available. Experien
ce over the last few years suggests, however, that reliable and easily
interpretable images are difficult to obtain. In particular, substrat
e condition, conduction mechanisms of the molecular species, and molec
ule-surface or tip-molecule interactions can give problems. In this pa
per we discuss how uncertainties of these types may be minimised, and
hence what kinds of molecules and substrates may be used to obtain rep
eatable and reliable images.