SYNTHESIS AND REACTIONS OF 7-CHLORO-5-HYDTHIOXO-3H-1,2,3,5-TETRAHYDRO[1,2,4]TRIAZOLO[5,1-B] QUINAZOLINES

Reactions of ro-4-phenyl-2-thioxo-1,2,3,4-tetrahydroquinazoline with a rylisocyanate or arylisothiocyanate afforded unknown 1-substituted oro -5-hydroxy-2-oxo-5-phenyl-3H-1,2,3,5-tetrahydro [1,2,4]triazolo[5,1-b] quinazolines or enyl-2-thioxo-3H-1,2,3,5-tetrahydro[1,2,4]triazolo [5, 1-b]quinazolines. The reaction of 2-amino-5-chloro-benzophenonehydrazo ne with phenylisothiocyanate depended on reaction conditions and affor ded roxy-2-thioxo-3H-1,2,3,5-tetrahydro[1,2,4)triazolo [5,1-b]quinazol ine or 2,3,5-tetrahydro[1,2,4]triazolo[5,1-b]quinazoline. 1-Substitute d 2,3,5-tetrahydro[1,2,4]triazolo[5,1-b]quinazolines gave with iodoalk anes in corresponding alcohols 1-substituted 5-alkoxy-2-alkylthio-7-ch loro-5-phenyl-1, 5-dihydro[1,2,4]triazolo[5,1-b]quinazolines. Further the alkylthio-groups were substituted by amines.