ANTAGONISTIC EFFECT OF A VASOACTIVE-INTESTINAL-PEPTIDE FRAGMENT, VASOACTIVE INTESTINAL PEPTIDE(1-11), ON GUINEA-PIG TRACHEA SMOOTH-MUSCLE RELAXATION

Authors
GOOSSENS JF POMMERY N LOHEZ M POMMERY J HELBECQUE N COTELLE P LHERMITTE M HENICHART JP
Citation
Jf. Goossens et al., ANTAGONISTIC EFFECT OF A VASOACTIVE-INTESTINAL-PEPTIDE FRAGMENT, VASOACTIVE INTESTINAL PEPTIDE(1-11), ON GUINEA-PIG TRACHEA SMOOTH-MUSCLE RELAXATION, Molecular pharmacology, 41(1), 1992, pp. 104-109
Citations number
45
Journal title
Molecular pharmacology → ACNP
ISSN journal
0026895X
Volume
41
Issue
1
Year of publication
1992
Pages
104 - 109
Database
ISI
SICI code
0026-895X(1992)41:1<104:AEOAVF>2.0.ZU;2-G
Abstract
The conformation of various regions of vasoactive intestinal peptide ( VIP) has been analyzed by semiempirical methods, CD, and NMR spectrosc opy, indicating that residues 11-21 are most likely to be helical, whe reas the amino-terminal portion VIP(1-11) could exhibit two beta-turn structures. VIP(1-11) inhibits I-125-VIP binding to intact guinea pig tracheal epithelial cells and the VIP-induced smooth muscle response. However, the endecapeptide exhibits no effect on the muscle tone. All these data suggest that VIP(1-11) may be a useful tool in studying VIP receptor recognition, its regulation, and cellular functions.