THE EFFECT OF ETOMOXIR ON INSULIN SENSITIVITY IN TYPE-2 DIABETIC-PATIENTS

Oral application of 50 mg Etomoxir caused a significant rise (33.1%) o f insulin-mediated glucose uptake. This was shown in a placebo-control led, double-blind randomized study in 8 type 2 diabetic patients by us ing the euglycemic clamp technique. The mean metabolic clearance rate of glucose (MCR) was raised from 4.1 +/- 0.9 mg/(kg.min) to 5.4 +/- 1. 2 mg/(kg.min) (x +/- SEM, P = 0.039). Plasma levels of free fatty acid s (FFA), glucose counterregulatory hormones, lipids and C-peptide valu es during the clamps were not different after verum and placebo. We co nclude that Etomoxir improves insulin sensitivity in type 2 diabetic p atients.