SUBCHRONIC ORAL-ADMINISTRATION OF ACEMANNAN IN THE RAT AND DOG

Acemannan is the USAN-accepted name for long-chain polydispersed beta- (1, 4)-acetylated polymannose with interspersed 0-acetyl groups, with a mannose monomer/acetyl ratio of approximately 1:1. This complex poly saccharide is extracted from Aloe vera (barbadensis Miller); the techn ical material contains approximately 78% acemannan. Technical grade ac emannan was administered po to rats for 14 d at 5% of the diet and for 6 mo at up to 2,000 mg/kg/d, and to beagle dogs for 90 d at up to 1,5 00 mg/kg/d without significant effect on any parameter measured in eit her species.